Renal Toxicogenomic Response to Chronic Uranyl Nitrate Insult in Mice
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چکیده
منابع مشابه
Renal Toxicogenomic Response to Chronic Uranyl Nitrate Insult in Mice
Although the nephrotoxicity of uranium has been established through numerous animal studies, relatively little is known about the effects of long-term environmental uranium exposure. Using a combination of conventional biochemical studies and serial analysis of gene expression (SAGE), we examined the renal responses to uranyl nitrate (UN) chronic exposure. Renal uranium levels were significantl...
متن کاملThe Mechanism of Acute Renal Failure after Uranyl Nitrate ROLAND
Portions of this work were presented at the Annual Meeting of The American Federation for Clinical Research, Atlantic City, N. J., 5 May 1974. Received for publication 21 June 1974 and in revised form 18 November 1974. dose UN (0.047±0.013) and high dose (0.024±0.003 nVs/g kidney wt/mm Hg). Therefore UN decreases GFR by two mechanisms: (a) tubular damage leading to back-diffusion of solutes and...
متن کاملCell division and phenotypic regression of proximal tubular cells in response to uranyl acetate insult in rats.
BACKGROUND We examined whether dedifferentiation is necessary for cell division of proximal tubule (PT) cells after acute PT injury. METHODS Rats were injected with a low (0.2 mg/kg) or high (4 mg/kg) dose of uranyl acetate (UA) to induce acute PT injury. Proliferating PT cells were labelled with bromodeoxyuridine (BrdU) before sacrifice. Renal tissues were examined by double labelling of Brd...
متن کاملGlomerular endothelial cells in uranyl nitrate-induced acute renal failure in rats.
In uranyl nitrate (UN)-induced acute renal failure (ARF) glomerular ultrafiltration coefficient (K(f)) decreases because of unknown reasons. Since transport of water across the glomerular capillary wall occurs predominantly extracellularly through the endothelial fenestrae (EF), a reduction in the diameter and/or the density of EF can reduce the extracellular filtration area and the glomerular ...
متن کاملExperimental acute renal failure induced by uranyl nitrate in the dog.
The diminished glomerular filtration rate observed in previous studies of acute renal failure induced by uranyl nitrate has been ascribed to backflow of glomerular filtrate through necrotic tubular epithelium, since renal blood flow was essentially normal. Renal blood flow (xenon washout) and renal function were studied serially for 96 hours after the administration of uranyl nitrate (10 mg/kg,...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2004
ISSN: 0091-6765
DOI: 10.1289/ehp.7296